Metabolic Disease Drug Development - USA (October 2012 )

Expanding epidemic. Unmet medical need. Enormous market potential.

The combination of an escalating metabolic epidemic and limitations of current drugs has created an enormous market opportunity for drug developers.

Today, 34% of US adults have the metabolic syndrome, a constellation of symptoms including obesity, insulin resistance and dyslipidemia. Such figures are leading industry experts to predict that the global market of metabolic drugs will reach$138bn by 2016.

The current excitement generated by the enormous cardiometabolic market potential is tempered by apparent shortcomings in currently available drug classes. New metabolic therapies will have to demonstrate mechanisms of safe and significant glycemic and lipidemic efficacy. Drug developers will also have to understand and mitigate the CV risk associated with the major metabolic diseases in order to navigate the challenging regulatory environment.

We worked closely with senior figures at Merck, Boehringer Ingelheim, Johnson & Johnson, AstraZeneca and many others to construct an agenda which will address these concerns directly. As such, this meeting promises high level, commercially directed discussion of the most pressing technical and strategic issues at hand.

Attend this meeting to:

• Get expert insight from industry clinicians on how best to satisfy regulators and speed drugs to market
• Explore mechanisms of action of the latest T2DM and obesity drug classes to optimize your own drug development
• Uncover new pathways and druggable targets to replenish the obesity and T2DM pharmaceutical pipeline
• Hear from industry experts on how best to mitigate against the CV and systemic risk associated with metabolic drugs
• Increase efficiency by hearing from the leading solution providers
Who should attend this meeting:
• Drug developers focusing on developing novel metabolic drugs
• Scientists and academics working in diabetes, obesity and dyslipidemia
• Clinicians and CROs specializing in metabolic drug trials

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Targeting the Ubiquitin Pathway - USA ( October 1-2, 2012 )

Drugs targeting the ubiquitin system are still relatively new; the first approval by the FDA happened in 2003. Ubiquitination (ligases) as well as deubiquitination (deubiquitylating enzymes (DUBs) play key roles in cellular signal transduction pathways and offer numerous opportunities for therapeutic interventions for treating diseases such as cancer, inflammation and metabolic diseases. However, in order to bring more ubiquitin targeting drugs to the market, some challenges need to be addressed and will be discussed at this meeting.

Cambridge Healthtech Institute's Inaugural Targeting the Ubiquitin Pathway conference is focused on drug discovery and development within the ubiquitin related pathway, such as ubiquitin pathway inhibitors, targeting ubiquitin ligases and learning from case studies. We are bringing together experts from the pharmaceutical industry, biotech and academia to exchange knowledge, discuss current challenges and interact in focused breakout discussions, poster sessions and network receptions.

Topics will include:
- Screening for Ubiquitin Ligase Inhibitors
- Targeting E2 - E3 Interactions
- Targeting Deubiquitinases
- Developing Chemical Libraries to Target DUBs
- Targeting E1, E2 or E3 Ligases
- Developing Small Molecule Inhibitors
- Ubiquitin-Like Modifiers in Signaling
- Targeting Conjugation/Deconjugation
- Targeting the Ubiquitin - Proteas

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10th Functional Genomics Screening Strategies - USA

In the screening world there is definitely no one-size-fits-all and there is also no dearth of options to choose from to address your screening needs. So how do you decide which screening strategy to use? What factors help determine the right choice of assay platform, cells and reagents? Can different screening techniques be utilized in tandem or be staggered to better validate the results and overcome individual shortcomings? Which screening strategy will provide information that is most relevant and physiologically significant to your biological query? It is quite evident that there is an unmet need that can be addressed by getting together the right thought leaders in the field to discuss the informational gaps and the resources that can be leveraged to bridge these shortcomings.

Cambridge Healthtech Institute's 10th Annual Functional Genomics Screening Strategies, which previously covered only RNA Interference (RNAi) Screening, now covers the use of chemical genomics tools, cDNA overexpression assays and the potential use of micro RNA (miRNA) and long non-coding RNAs for identifying and validating drug targets, exploring unknown cellular pathways, and for performing translational studies such as biomarker discovery, drug modifier screens and more. Hear from the experts in industry and academia on how they are leveraging the utility of these diverse screens for a wide range of applications.

Session topics will cover:
- Functional genomics application for diverse biological questions
- Challenges in assay design and development
- Choosing the right cell, library and reagents for your screening efforts
- Informatics tools for screening data analysis and hit nomination
- Dealing with off-target effects and false positives: towards hit prioritization
- Hit validation: a post-genomic era of challenges and tribulations
- A need for gold standards and data quality control

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International Conference on Biothreats and Biodefense - USA

Biodefense-2012 will be the scientific platform bringing together the people sharing the agenda of live and let others live. The conference not only puts forth the ideas from scientific community but also welcomes the policy makers to explain the scientific decisions in the sociological context. The conference shares the opportunity to bring together the various scientific disciplines like Formal Sciences, Applied Sciences, Natural Sciences and Social Sciences from the academia, corporate, activists, NGOs and defense organizations to come up with a holistic approach to combat the threats created from the forms of life.

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3rd Pharmacokinetics & Pharmacodynamics Conference - Oct 24-26, 2012 USA

We welcome you to GTC's 3rd Pharmacokinetics & Pharmacodynamics Conference, taking place on October 24-26, 2012 in Philadelphia, PA. This year the conference is exclusively designed to showcase the state-of-the-art methodologies in the field of PK/PD, which would define the future of the field, and maximize the probability of achieving clinical success for drug companies. Cutting edge examples about the application of PK/PD analysis and modeling will be presented, that can help a drug company choose appropriate drug candidate, minimize clinical attrition, improve preclinical-to-clinical translation, and predict clinical outcome.

Key challenges faced by a PK/PD scientist will be addressed and approaches to overcome the challenges will be demonstrated. One would also learn about: (a) the use of PK/PD principles to overcome biological barriers e.g. BBB (b) effective translation of preclinical data into the clinic (c) utilization of PK/PD analysis and modeling to identify and validate appropriate biomarkers (d) perspective of the regulatory authorities regarding the use of PK/PD in streamlining the drug development (e) FIH dose prediction to achieve maximum efficacy and reduce the toxicity (f) development and utilization of systems pharmacology model to integrate known molecular pathways to validate drug targets.

The conference will be a very valuable tool for preclinical or clinical scientists and managers, working in the field of PK/PD, who are striving to use the PK/PD principles to minimize drug development risk and maximize clinical success. The sessions for our 2012 agenda are shown below.

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Conference on Stem Cells and Metabolism 2012

This Abcam sponsored meeting seeks to bring together researchers working in the fields of stem cells and metabolism for a 2 day intensive meeting to highlight the ways in which these two fields are rapidly converging.  The meeting will be organized into sessions that will cover basic metabolic processes, fundamental aspects of stem cell biology, as well as aging and diseases of aging.  The aim of the meeting is to engender discussions on how metabolic changes within stem cells can influence maintenance, proliferation, survival and the onset of differentiation, as well as how metabolic pathways can alter local and systemic environments, which ultimately impact stem cell behavior and tissue homeostasis.

With this meeting we will build a bridge between stem cell biology and metabolism - two key pillars of modern biology.

Our aims:

• Encourage numerous discussions in a relaxed atmosphere. In particular, to initiate discussions about metabolism as a regulator of stem cells and tissue homeostasis.
• Provide a unique opportunity for students and post-docs to participate and present their own data
• Inspire new collaborations and investigations within a new field of research

November 5, 2012

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9th Stem Cell Research & Therapeutics Conference - USA

We welcome you to GTC's 9th Stem Cell Research & Therapeutics Conference, taking place on October 24-26, 2012 in Philadelphia, PA. This forum presents information regarding cutting-edge developments in all areas of stem cell research including the biology, medicine, applications and regulations of stem cells. Recent developments in pre-clinical and clinical trials of stem cell therapy, regenerative medicine and tissue engineering, cancer stem cells, stem cell reprogramming, and regulatory policies regarding stem cell research will be addressed.

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4th Translational Medicine Conference - USA

GTCbio is proud to present our 4th Translational Medicine Conference to be held on October 24-26, 2012 in Philadelphia, PA. This meeting will bring together representatives from Pharma, government and leading academic institutions to cover a range of issues facing the field of translational science. Topics of discussion will include target identification and validation, predictive safety and toxicology, translation of animal models and the development of predictive preclinical models. Additionally, industry focused topics in biomarker development such as companion diagnostics for personalized medicine and industry-academic collaborations will be discussed.

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World Congress on Personalised Medicine & Molecular Diagnostics - USA

Personalised Medicines-2012 will serve as an impulse for the advancement of molecular analysis by connecting scientists all across the world at conferences and exhibitions that would create an environment conducive for information exchange, generation of new ideas and acceleration of applications.

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World iPS Cell Summit - USA

PS cells are completely changing the way we study disease and develop drugs. But understanding how to use this technology is critical.

The rapid progress in our understanding of iPS cell technology has been remarkable. But the next step is using iPS cells to meet research, therapeutic and commercial objectives.

So how are you keeping up to date with the latest advances? How are other drug developers generating and using iPS cells? What about applications in research?

In our research you told us that there is no other commercial event specifically designed to help the field drive forward the practical utility of iPS cells. Until now.

For the first time, the World iPS Cell Summit delivers 19 leading industry and academic speakers who will help you tackle the key issues in translating innovative iPS cell research into drug and therapeutic development. Arm yourself with the tools you need to advance your iPS cell reprogramming, differentiation, disease modeling and drug development approaches.

What's covered on the agenda?

- Pfizer, NIH, Roche, Novartis, Cedars-Sinai Medical Center and Takeda will discuss how they are successfully integrating iPS cells into drug discovery to improve drug screening and safety/toxicology assessments

- Explore how Tottori University is using human artificial chromosomes as new gene delivery vectors for iPS cell formation and learn from MSKCC about how you can generate safe iPS cells with efficient reprogramming techniques

- Pfizer, Novartis and AVEO Pharmaceuticals will compare the use of iPSCs and ESCs and discuss how stem cells are currently helping to establish reliable human models with better predictability

- Discover how iPS cells are being used to model diseases and obtain new insights into disease pathophysiology with The Whitehead Institute, McLean Hospital, Harvard University and Boston University School of Medicine

- Massachusetts General Hospital will outline how they are developing reproducible differentiation protocols and STEMCELL Technologies and University of California will discuss how you can control stem cell fate to generate specific cell lineages

- Understand how derivation and culture conditions can impact the number of genetic and epigenetic aberrations among hiPS cell lines and examine different approaches to suppress this variability with University of California and NIMH Stem Cell Resource, RUCDR

For more information, including the full speaker line up and final agenda, please visit: www.ipscell-summit.com

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USA : International Expo & Conference on Analytrix and HPLC

Analytrix-2012 is a remarkable event which brings together a unique and International mix of large and medium Pharmaceutical industries, diagnostic companies, leading universities and research institutes making the conference a perfect platform to share experience, foster collaborations across industry and academia, and evaluate emerging technologies across the globe.
Additional Information Dates of the Conference:October 22-24, 2012
Venue of the Conference: DoubleTree by Hilton Chicago-North Shore, USA
Theme:Recent Advances and Approaches in HPLC and other Analytical technique


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USA : International Conference on Clinical and Cellular Immunology

Immunology-2012 will be an innovative and invigorating international congress reflecting the direction of immunology in the 21st century in a secure yet exciting environment that offers a wide range of diversions to participants of all backgrounds.

This will be an excellent opportunity to meet leading scientists in the field of immunology and learn about the latest technological advances for people with immunological problems. The different tracks are arranged in an interdisciplinary manner to allow delegates to explore issues directly connected to their own areas of work. They also provide an opportunity to engage with other professionals from a wide range of disciplines.

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Lab-on-a-Chip World Congress - LOACWC 2012, USA

Welcome to the Lab-on-a-Chip World Congress and exhibition. This year's event will be held in San Diego.

The Lab-on-a-Chip World Congress will bring together leaders from both academia and industry to discuss innovative developments in this exciting field, with presentations exploring the latest advances in microfluidics and microfabrication. Attention will also be given to some of the many applications of Labs-on-Chips, from the enhancement of life science research, to taking diagnostics to the point of need.

The conference will be co-located with Microarray World Congress, Molecular Diagnostics World Congress and Single Cell Analysis Summit. Registered delegates will have access to all four meetings ensuring a very cost-effective trip.

For more information click here

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International Expo & Conference on Analytrix and HPLC 2012 - USA

Analytrix-2012 is a remarkable event which brings together a unique and International mix of large and medium Pharmaceutical industries, diagnostic companies, leading universities and research institutes making the conference a perfect platform to share experience, foster collaborations across industry and academia, and evaluate emerging technologies across the globe.
Additional Information Dates of the Conference:October 22-24, 2012
Venue of the Conference: DoubleTree by Hilton Chicago-North Shore, USA
Theme:Recent Advances and Approaches in HPLC and other Analytical techniques

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International Conference on Clinical and Cellular Immunology 2012 - USA

Immunology-2012 will be an innovative and invigorating international congress reflecting the direction of immunology in the 21st century in a secure yet exciting environment that offers a wide range of diversions to participants of all backgrounds.

This will be an excellent opportunity to meet leading scientists in the field of immunology and learn about the latest technological advances for people with immunological problems. The different tracks are arranged in an interdisciplinary manner to allow delegates to explore issues directly connected to their own areas of work. They also provide an opportunity to engage with other professionals from a wide range of disciplines.

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ACM International Conference On Bioinformatics, Computational Biology, and Biomedicine - USA

=== Call for Papers, Posters, Tutorials and Workshops ===

ACM International Conference On Bioinformatics, Computational Biology,
and Biomedicine (ACM-BCB 2012)

October 7-10 2012
Embassy Suites, Downtown Orlando, FL
ACM-BCB Website: http://www.cse.buffalo.edu/ACM-BCB2012

ACM BCB is the main flagship conference of the ACM SIG Bioinformatics.
The conference will provide a premier forum for interdisciplinary and
multidisciplinary research encompassing disciplines of computer
science, mathematics, statistics, biology, bioinformatics, and
biomedicine. The last two decades have led to a tremendous growth in
the size and dimensionality of biological and biomedical data. This
conference serves to provide information on leading edge in research
in processing, modeling and analyzing these datasets for a variety of
applications. We invite contributed papers, posters, workshops and
tutorials in the topic areas listed below. Please refer to the
conference website for more details. We also invite contributed
presentations for papers that have been published in a journal after
January 1, 2012. Only one page abstracts for these papers will appear
in the proceedings. Please refer to the conference website for more
details.

== Key Dates ==
Workshop proposals: Feb. 14, 2012
Paper Submission: May 14, 2012
Poster Submission: June 16, 2012
Notification to Authors: July 16, 2012

== Topics ==
Genomics and Evolution
Protein and RNA Structure, Protein Function, and Proteomics
Computational Systems Biology
Next Generation Sequencing Data
Medical Informatics and Translational Bioinformatics
Cross-Cutting Computational Methods
Bioinformatics Infrastructure
Immunoinformatics and Computational Immunology
Computational Epidemiology
Image Analysis
Knowledge Representation and Inference
Integration of Biomedical Data
Databases, Knowledgebases & Ontologies
Text Mining and Natural Language Processing

== Organizing Committee ==
Steering Committee Chair: Aidong Zhang, State University of New York at Buffalo
General Chair: Sanjay Ranka, University of Florida
Program Co-chairs: Tamer Kahveci, University of Florida and Mona
Singh, Princeton University
Workshop Chair: Vasant Honavar, Iowa State University
Publicity Chair: Mehmet Koyuturk, Case Western Reserve University
Local Arrangement Chairs: Hu Haiyan, Unviersity of Central Florida and
Xiaoning Qian, University of South Florida
Registration Chair: Preetam Ghosh, VCU
Proceedings Chair: Jing Gao, State University of New York at Buffalo

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International Conference on Emerging Cell Therapies 2012 - USA

Cell Therapy-2012 is a remarkable event which brings together a unique and International mix of large and medium Biomedicine, Molecular Cell Biology and Regenerative medicine, leading Universities and cell therapy institutions making the Congress a perfect platform to share experience and which paves a way to gather visionaries through the research talks and presentations and put forward many thought provoking statergies in Emerging Cell Therapies.

The Conference aims to serve as a catalyst for the advancement in Emerging Cell Therapies by connecting scientists within and across disciplines at conferences held under a single roof that create an environment conducive to information exchange, generation of new ideas and acceleration of applications that benefit society. Conference Highlights the following topics:
• Gene & Cell Therapy
• Stem Cell Therapies
• Cellular Therapies
• Cancer Cell Therapies
• Pharmacologically Regulated Cell Therapy
• Nanoremedies
• Bioengineering Cell Therapy
• CellTherapy in Future Medicine
• Cell Therapy- Ethics & Religion
• Regulatory & Economic Aspects
• Current Research & Future perspectives on Cell Therapy

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International Integrative Biology Summit 2012 - USA

OMICS Group invites all the participants across the globe to attend the International Integrative Biology Summit during October 1-3, 2012, DoubleTree by Hilton Chicago-North Shore, USA

International Integrative Biology Summit will provide a unique platform for scientists/experts from academia and industry nationwide to catalyze the networking between the branches of computational biology and bioinformatics and to facilitate the amalgamation of the complementary scientific efforts in the academia and industry to achieve common scientific goals.

It gives the opportunity to participate in a congress with fellow colleagues, delegates, exhibitors and leading scientists in the field of integrative biology. OMICS International Integrative Biology Summit will schedule and coordinate all meetings with our Editorial Board Members and other experts in the integrative biology field across the World. The scientific programme paves a way to gather visionaries through the research talks and presentations and put forward many thought provoking strategies in Integrative Biology.

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6th Next-Generation Histone Deacetylase Inhibitors meet - USA

Histone deacetylases (HDACs) have proven to be a promising target for drug intervention and there are a number of HDAC inhibitors (HDACi) being tested in the pre-clinical and clinical stages. HDACi were primarily developed as anti-tumor agents for cancer, but many are now being explored for treating CNS, immunologic, metabolic, inflammatory and cardiovascular disorders. However, much remains to be elucidated about the functional implications of modulating HDACs and understanding the signaling pathways that can cause adverse cellular effects.

Program topics will include:
- Understanding the mechanism of HDAC inhibition
- Screening for HDAC inhibition: Use of animal models and in vitro assays
- Using structural biology to guide chemical design
- Challenges with achieving isoform selectivity and specificity
- Evaluating the use of pan versus isoform-specific inhibitors
- Experimenting with monotherapy and combination therapies
- Update on novel HDACi and their progress towards the clinic
- Tracking the progress of HDACi for non-oncology indications
- Targeting Sirtuins: Emerging role in various diseases
- Addressing safety concerns at the pre-clinical and clinical stages
- Developing surrogate biomarkers for patient response and resistance
- Adverse effects in the clinic and issues with patient compliance

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Cambridge Healthtech Institute's Inaugural Targeting the Ubiquitin Pathway conference 2012

Drugs targeting the ubiquitin system are still relatively new; the first approval by the FDA happened in 2003. Ubiquitination (ligases) as well as deubiquitination (deubiquitylating enzymes (DUBs) play key roles in cellular signal transduction pathways and offer numerous opportunities for therapeutic interventions for treating diseases such as cancer, inflammation and metabolic diseases. However, in order to bring more ubiquitin targeting drugs to the market, some challenges need to be addressed and will be discussed at this meeting.

Cambridge Healthtech Institute's Inaugural Targeting the Ubiquitin Pathway conference is focused on drug discovery and development within the ubiquitin related pathway, such as ubiquitin pathway inhibitors, targeting ubiquitin ligases and learning from case studies. We are bringing together experts from the pharmaceutical industry, biotech and academia to exchange knowledge, discuss current challenges and interact in focused breakout discussions, poster sessions and network receptions.

Topics will include:
- Screening for Ubiquitin Ligase Inhibitors
- Targeting E2 - E3 Interactions
- Targeting Deubiquitinases
- Developing Chemical Libraries to Target DUBs
- Targeting E1, E2 or E3 Ligases
- Developing Small Molecule Inhibitors
- Ubiquitin-Like Modifiers in Signaling
- Targeting Conjugation/Deconjugation
- Targeting the Ubiquitin - Proteasome Pathway
- Bortezomib - Lessons Learned

Further details and to register

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